Work

Luspatercept ameliorates disease phenotype and complications in the Townes mouse model of sickle cell disease

Year: 2026

Type: article

Abstract: Preclinical data demonstrating that luspatercept mitigates vaso-occlusive and anemia-related complications in the Townes sickle cell model provide a strong rationale for its evaluation in SCD patients.

Source: Journal of Clinical Investigation

DOI: 10.1172/jci197706

Authors: Maiko Sezaki, Tian Li, Mingzhe Pan, Zhihong Wang, Jie Bai, Justin G. Horowitz, Julia Z. Xu, Gang Huang

Institutions: The University of Texas at San Antonio Health Science Center, Fujian Provincial Hospital, University of Pittsburgh

Language: English

Topic: Hemoglobinopathies and Related Disorders

Subfield: Genetics

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $5,200

Funders: U.S. Department of Defense, National Institutes of Health, National Cancer Institute

Awards: Mays Cancer Center at UT Health SA, G5635148292, G9000199679, G9000237056, G9000324485, The Role of HIF1A-DNMT3A axis in AML1/ETO-Driven Acute MyelogenousLeukemia, Role of an Aberrant N6-Methyladenosine-LncRNA Axis in the Development and Maintenance of Drug Resistance through Regulating the Leukemia Stem Cell

OpenAlex ID: W7127044152

FWCI:

Cites: 5

Cited by:

Related to: