Target Trial Emulation for the Estimation of Drug Effects in Pregnancy and Perinatal Outcomes
Year: 2026
Type: article
Abstract: Pregnant women are commonly excluded from pre-approval randomised clinical trials; therefore, post-approval studies often rely on real-world data (RWD).Target trial emulation (TTE) has become a widely adopted conceptual framework for causal inference, and its implementation in pregnancy studies necessitates consideration of certain nuances, as illustrated in an accompanying study by DiTosto et al. [1] In this commentary, we expand the overall description of the framework, including its limitations, and elaborate on specific features for pregnancy studies, with emphasis on sequential emulation.
DOI: 10.1111/ppe.70116
Authors: Xabier Garcia‐Albeniz, Andrea Margulis
Institution: RTI Health Solutions
Language: English
Subfield: Statistics and Probability
Field: Mathematics
Domain: Physical Sciences
Open Access status: bronze
OpenAlex ID: W7127044337