Improved polygenic risk prediction models for breast cancer subtypes in women of African ancestry
Year: 2026
Type: article
Study design: Observational Study
Source: Nature Genetics
Authors: James L. Li, Haoyu Zhang, Xiaoyu Wang, Guochong Jia, Julian C. McClellan, Wenji Guo, Yijia Sun, Peter N. Fiorica, Stefan Ambs, Mollie E. Barnard, Yu Chen, Montserrat Garcia-Closas, Jian Gu, Jennifer J. Hu, Esther M. John, Katherine L. Nathanson, Barbara Nemesure, Tuya Pal, Xiao-Ou Shu, Michael F. Press, Maureen Sanderson, Dale P. Sandler, Melissa A. Troester, Song Yao, Jirong Long, Thomas U. Ahearn, Abenaa M. Brewster, Adeyinka Falusi, Peter Kraft, Anselm J. M. Hennis, Timothy Makumbi, Berthe S. E. Mapoko, Katie M. O’Brien, Oladosu Ojengbede, Andrew F. Olshan, Sonya Reid, Gary Zirpoli, Qiuyin Cai, Eboneé N. Butler, Maosheng Huang, John Obafunwa, Clarice R. Weinberg, Christine Ambrosone, Jie Ping, Ran Tao, Bingshan Li, Xingyi Guo, Guimin Gao, David V. Conti, Nilanjan Chatterjee, Julie R. Palmer, Olufunmilayo I. Olopade, Wei Zheng, Christopher A. Haiman, Dezheng Huo
Institutions: University of Chicago, National Institutes of Health, Division of Cancer Epidemiology and Genetics, Frederick National Laboratory for Cancer Research, Leidos Biomedical Research Inc. (United States), Vanderbilt University, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, University at Buffalo, State University of New York, National Cancer Institute, Center for Cancer Research, Boston University, New York University, Institute of Cancer Research, The University of Texas MD Anderson Cancer Center, University of Miami, Stanford Medicine, Stanford University, Abramson Cancer Center, University of Pennsylvania, Stony Brook University, University of Southern California, USC Norris Comprehensive Cancer Center, Meharry Medical College, National Institute of Environmental Health Sciences, University of North Carolina at Chapel Hill, UNC Lineberger Comprehensive Cancer Center, Roswell Park Comprehensive Cancer Center, University of Ibadan, Institute for Advanced Medical Research and Training, University of the West Indies, Mulago Hospital, Central Hospital of Yaoundé, Lagos University Teaching Hospital, Lagos State University Teaching Hospital, Johns Hopkins University
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: green
Funders: U.S. Department of Defense, U.S. Department of Health and Human Services, Susan G. Komen for the Cure, Breast Cancer Research Foundation, Vanderbilt University, Vanderbilt-Ingram Cancer Center, Duncan Family Institute for Cancer Prevention and Risk Assessment, Susan G. Komen, Tower Cancer Research Foundation, Vanderbilt University Medical Center, Georgia Clinical and Translational Science Alliance, USC Norris Comprehensive Cancer Center, National Institutes of Health, University of Texas MD Anderson Cancer Center, National Human Genome Research Institute, National Cancer Institute, National Institute of Neurological Disorders and Stroke, National Center for Advancing Translational Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development
Awards: G1060157190, G1253072103, G1392998430, BREAST CANCER RISK FACTORS IN HISPANIC WOMEN, G1531600799, G1538231741, G1554522753, G1569999668, G1684255760, G1766209448, G2103760183, G2144275393, G2202281228, Understanding the genetic risk underlying racial disparities in uterine fibroids, G231467711, G2342729008, G2461086968, G254564584, G2615776415, G2621372507, G2683268942, G2822312608, G2926448989, G3086620026, Consortium Study to Identify Breast Cancer Susceptibility Loci, G3269002440, G3395468139, G3619590958, G364208108, G3678119284, G3687380347, G3724712001, G3791753988, G3828336601, G3938985443, G3955445105, G4049315607, G411556232, G4185755830, G4219670862, Automated Storage and Retrieval of Biological Systems, G429713427, G4395870004, G4410787187, G4712798043, Transcriptome-wide association studies and genetic risk prediction for breast cancer integrating RNA splicing and gene expression from multiple tissues, G4826281220, G5006584880, G5057854426, BioVU Plasma Storage Equipment, G5125508312, G5305488713, G530910684, The Nashville Breast Health Study, G5554707783, G5601528875, G5604747201, G560889077, G5679716143, G5694555675, G5717004637, G5836777982, Genetic Epidemiology of Multiple Sclerosis, G6012122791, G6288781261, G6589054092, G6824230748, G6951645729, G7163342664, G7168644870, G725763919, G7302486225, Epidemiology of Breast Cancer Subtypes in African American Women: a Consortium, G7566532274, The Vanderbilt Institute for Clinical and Translational Research (VICTR), Improving Breast Cancer Risk Prediction for African American Women: Consideration of Estrogen Receptor Subtype-Specific Risk Factors, G7979917349, G8098630230, G8183463779, Epidemiologic Architecture for Genes Linked to Environment (EAGLE), G8332127685, G8382600636, G8512272119, G8577957303, Modular Automated -80C Sample Storage System, G9000006672, G9000008449, G9000022573, G9000022789, G9000023679, G9000027691, G9000043901, G9000054231, G9000064184, G9000084438, G9000090229, G9000108948, G9000117861, G9000160301, G9000167145, G9000176506, G9000179242, G9000192259, G9000194218, G9000209945, G9000219434, G9000244483, G9000259914, G9000273412, ChicAgo Center for Health and EnvironmenT (CACHET), University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG), (2/3) MMC, VICC, and TSU: Partners in Eliminating Cancer Disparities, G908924418, G95160140, Etiology and Genomics of Breast Cancer Progression in Women of African Ancestry
OpenAlex ID: W7127075929