Work

Chimeric Glycoprotein Nanoparticles Elicit Robust Neutralizing Antibodies Against Epstein–Barr Virus (Adv. Mater. 7/2026)

Year: 2026

Type: article

Abstract: EBV Vaccine Cong Sun, Zheng Liu, Mu-Sheng Zeng, and colleagues design a chimeric nanoparticle displaying multiple EBV glycoproteins in virion-mimicry pattern. It induces potent neutralizing antibodies against Epstein-Barr virus. This vaccine offers a new strategy to comprise multiple antigens upon nanoparticle to induce a native virus-like humoral response with enhanced immunogenicity. The cover image depicts battles between warriors and monster Tao-Wu from ancient Chinese myth. EBV, like monster Tao-Wu is difficult to fight, and the warrior use shield made from the horns of monsters to show the use of glycoproteins of EBV to efficiently combat with it. More details can be found in the Research Article (DOI: 10.1002/adma.202507012).

Source: Advanced Materials

DOI: 10.1002/adma.72130

Authors: Cong Sun, Chu Xie, Xin‐Yan Fang, Dong‐Chun Hong, Haoyu Zhang, Pei‐Huang Wu, Yi‐Na Liu, Guo‐Long Bu, De‐Hai Cao, Min‐Yi Si‐Tu, Yong‐Jian Peng, Jing Wang, Guo‐Kai Feng, Qian Zhong, Zheng Liu, Mu‐Sheng Zeng

Institutions: Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Southern University of Science and Technology

Language: English

Topic: Viral-associated cancers and disorders

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W7127090058

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