Histopathological evaluation of lower limb reticular veins treated with Nd:YAG 1064 nm laser: a prospective cohort pilot study
Year: 2026
Type: article
Abstract: BACKGROUND: The 1064 nm Nd:YAG transdermal laser is commonly used in the ambulatory treatment of lower limb reticular veins and telangiectasias. However, optimal laser parameters, particularly fluence and pulse duration, remain a subject of debate. In this prospective cohort pilot study, we evaluated the histopathological effects of different Nd:YAG 1064 nm laser settings on reticular veins to identify the parameter combinations most associated with vein wall damage. METHODS: Patients scheduled for ambulatory phlebectomy received transdermal laser therapy 24 hours prior to surgery, using different combinations of fluence and pulse duration. A total of 15 vein segments were collected during phlebectomy, 12 treated with the laser and 3 untreated controls. All samples were stained with hematoxylin and eosin and independently analyzed by two blinded pathologists for neutrophilic infiltration, luminal thrombosis, and wall fibrosis. RESULTS: with pulse durations of 15 ms and 30 ms were significantly associated with the presence of inflammatory infiltrates (P<0.05). No statistically significant differences were found when comparing fixed fluence with variable pulse durations or fixed pulse duration with variable fluences (P>0.05). CONCLUSIONS: combined with pulse durations of 15-30 ms.
Source: International Angiology
Authors: Felipe COELHO, Fernando T. SILVEIRA, Paulo R. BIGNARDI, Glenio B. MIZUBUTI, Carlos E. VIRGINI-MAGALHÃES, Douglas POSCHINGER-FIGUEIREDO, Eduardo de O. RODRIGUES, Rodrigo G. de OLIVEIRA
Language: English
Subfield: Surgery
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W7127090064