Work

A Cell‐Intrinsic Role for RANK in Regulatory T Cells of the Human Thymus

Year: 2026

Type: article

Abstract: We identified RANK (TNFRSF11a) expression in human thymic FOXP3+ Tregs, revealing a previously unknown role for the RANK-RANKL axis in human tTreg development. We show that IL-2 and IL-15 can drive RANK expression in CD4+ tTregs, which in turn may modulate their maturation and proliferation within the thymic environment. Created in BioRender. Biorender, I. (2026) https://BioRender.com/gbrjlpa.

Source: European Journal of Immunology

DOI: 10.1002/eji.70132

Authors: Zoe‐Isabella Junginger, Ramona Adameck, Alexandre A. S. F. Raposo, Pedro Rosmaninho, Ana E. Sousa, Afonso R. M. Almeida

Institutions: University of Lisbon, Gulbenkian Institute for Molecular Medicine

Language: English

Topic: T-cell and B-cell Immunology

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,550