Work

Microbial influences on chronic rhinosinusitis

Year: 2026

Type: article

Abstract: The nasal microbiome is altered in chronic rhinosinusitis (CRS), characterized by increased bacteria density and higher relative abundance of Staphylococcus aureus compared to healthy adults. This review examines determinants of S aureus nasal colonization, focusing on immune control and its evasion by the bacteria. CRS and asthma share pathomechanisms of chronic airway inflammation and often co-occur. In both conditions, many patients are sensitized to secreted factors of S aureus enterotoxins and serine protease-like proteins, and produce specific IgE, which influences the disease course. Therefore, we propose to incorporate S aureus-specific IgE measurements into the routine diagnostic evaluation of CRS and asthma.

Source: Journal of Allergy and Clinical Immunology

DOI: 10.1016/j.jaci.2026.01.019

Authors: Barbara M. Bröker, Claus Bachert

Institutions: Universitätsmedizin Greifswald, Universität Greifswald, Sun Yat-sen University, University Hospital Münster, The First Affiliated Hospital, Sun Yat-sen University

Language: English

Topic: Sinusitis and nasal conditions

Subfield: Otorhinolaryngology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $4,900