Work

Nanomedicine Meets Immunotherapy: Transforming Chimeric Antigen Receptor T Cell Treatment for Solid Tumors

Year: 2026

Type: article

Abstract: The emergence of effective immunotherapies has drastically revolutionized clinical management of many cancer types. Among them, chimeric antigen receptor (CAR)-T cell therapy (CTT), as a groundbreaking approach, has been considered as a "living drug," displaying unprecedented clinical outcomes with hematological malignancies, including B cell leukemia and lymphomas, and multiple myeloma. Despite the high remission rates and improved survival achieved with hematological cancers, the effectiveness of CTT in solid tumors remains largely unsatisfactory. The efficacy of CTT in solid tumors is significantly challenged by multiple factors, including tumor-antigen heterogeneity, limited T cell trafficking and infiltration, a highly immunosuppressive tumor microenvironment, and the risk of severe adverse effects. Accumulating evidence highlights the potential of nanotechnology to address these obstacles, paving the way for more effective CTT against solid tumors. Thus, this review explores to highlight the evolution and challenges of CTT in solid tumors, while summarizing the up-to-date advances of nanotechnology-enabled CTT with the intention towards the formulation of a more cohesive, personalized, and effective cancer therapy in the future.

Source: Small Science

DOI: 10.1002/smsc.202500596

Authors: Stephen O’Rourke, Nuo Xu, Hongjun Wang, Hexin Chen

Institutions: University of South Carolina, Stevens Institute of Technology

Language: English

Topic: CAR-T cell therapy research

Subfield: Oncology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $6,350