Work

The Introduction of Creatinine Clearance to Estimate Kidney Function

Year: 2026

Type: article

Abstract: In 1914, Thomas Addis famously remarked that all we know for certain about the kidney is that it makes urine. More than a reflection of humility, this statement captured the state of uncertainty regarding kidney physiology at the time. Over a decade later in 1926, Poul Brandt Rehberg submitted his doctoral thesis, Studies on Kidney Function, where he described a method to measure the GFR. This Perspective marks the 100-year anniversary of Poul Brandt Rehberg's dissertation, wherein he introduced creatinine clearance as a method to estimate GFR and made critical contributions toward understanding the mechanisms underlying urine formation

Source: Journal of the American Society of Nephrology

DOI: 10.1681/asn.0000001043

Authors: Henrik Dimke, Henrik Knudsen, Tobias Wang

Institutions: University of Southern Denmark, Odense University Hospital, Statens Arkivers, Aarhus University

Language: English

Topic: History of Science and Medicine

Subfield: History and Philosophy of Science

Field: Arts and Humanities

Domain: Social Sciences

Open Access status: green

OpenAlex ID: W7127130356

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