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Comparative Effectiveness of Myopia-control Spectacle Lenses: Clincial Setting Performance from a Retrospective Cohort Study

Year: 2026

Type: article

Abstract: Purpose: To compare the clincial setting effectiveness of three myopia control spectacle lenses, defocus incorporated multiple segments (DIMS), highly aspherical lenslet target (HALT), and cylindrical annular refractive elements (CARE), versus single-vision lenses (SVLs) in attenuating axial elongation and myopic refractive shift in children. Design: A single-center, retrospective cohort study. Participants: A total of 899 subjects (1780 eyes) aged 6-16 years with cycloplegic spherical equivalent (SE) between -0.50 D and -9.00 D. Subjects were divided into four groups based on prescribed eyewear: SVL (n = 446 eyes), DIMS (n = 523 eyes), HALT (n = 295 eyes), and CARE (n = 516 eyes). Methods: Data were extracted from electronic medical records. Longitudinal changes in axial length (AL) and SE refraction were analyzed using linear mixed-effects models to compare progression rates among the lens types, adjusting for baseline age, sex, parental myopia, and the baseline value of the respective outcome variable. Main Outcome Measures: Annualized rate of progression in AL (mm/year) and SE (D/year). Results: > 0.13). Conclusions: Highly aspherical lenslet target, DIMS, and CARE effectively slowed progression versus SVL, with HALT showing the greatest AL control. While the retrospective design warrants cautious interpretation, results support the use of all three lenses. Future prospective head-to-head studies are needed to clarify durability and optimal combination strategies. Financial Disclosures: The authors have no proprietary or commercial interest in any materials discussed in this article.

Source: Ophthalmology Science

DOI: 10.1016/j.xops.2026.101103