Work

B(C 6 F 5 ) 3 ‐Catalyzed Cross‐Dehydrogenative Coupling of Arenes and Phosphites With Tetrahydroisoquinolines

Year: 2026

Type: article

Abstract: Cross‐dehydrogenative coupling (CDC) reactions have emerged as a powerful strategy for direct CH functionalization, yet many approaches rely on harsh oxidants, light‐driven processes, or expensive electrochemical setups, which limit their applicability. Here, we report a B(C 6 F 5 ) 3 ‐catalyzed approach that enables efficient α‐hydride abstraction of N ‐aryl tetrahydroisoquinolines under mild conditions. Mechanistic studies suggest that the reaction proceeds through the formation of an iminium ion. Overall, this work establishes a practical and sustainable approach to CDC reactions, highlighting the potential of B(C 6 F 5 ) 3 catalysis for direct CH functionalization.

Source: Advanced Synthesis & Catalysis

DOI: 10.1002/adsc.70288

Authors: Riya Rakheja, Swagata Maity, Pragya Sharma, Chinmoy Kumar Hazra

Institution: Indian Institute of Technology Delhi

Language: English

Topic: Catalytic C–H Functionalization Methods

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funders: Arthritis National Research Foundation, Ministry of Education, India, Indian Institute of Technology Delhi

Award: G1685227528