Work

Targeting the gut microbiota in type 1 diabetes mellitus: Therapeutic potential of probiotics and prebiotics

Year: 2026

Type: article

Abstract: Type 1 diabetes mellitus (T1DM) management faces limitations with conventional insulin therapy, prompting exploration of novel strategies targeting gut microbiota dysregulation. Accumulating evidence indicates that gut microbial alterations significantly compromise intestinal barrier integrity and immune homeostasis, contributing to T1DM pathogenesis. Probiotics and prebiotics emerge as promising modulators of gut-islet axis function, though their mechanisms for restoring mucosal tolerance require further elucidation. Persistent translational challenges include strain specificity and treatment individualization. This review synthesizes evidence on microbiota-β cell-immune interactions to establish a framework for targeted microbial therapeutics in T1DM.

Source: EngMedicine

DOI: 10.1016/j.engmed.2026.100122

Authors: Xizhen Tan, Lingxiang Xie, Yang Xiao

Institutions: Central South University, Second Xiangya Hospital of Central South University

Language: English

Topic: Gut microbiota and health

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,300