Work

Generation of two induced pluripotent stem cell (iPSC) lines (HZSMHCI001-A and HZSMHCI004-A) from a mother–child dyad with major depressive disorder and bipolar disorder

Year: 2026

Type: article

Abstract: Bipolar disorder (BD) and major depressive disorder (MDD) are severe, heritable psychiatric illnesses. Here, we report the generation of two induced pluripotent stem cell (iPSC) lines from peripheral blood mononuclear cells of a female with MDD (HZSMHCI004-A) and her son with BD (HZSMHCI001-A). Reprogramming was achieved using non-integrating episomal vectors. Both iPSC lines exhibit normal karyotypes, express key pluripotency markers, and demonstrate the capacity to differentiate into derivatives of all three germ layers in vivo via teratoma formation assays. These cell lines represent a valuable resource for investigating the distinct and shared pathophysiology of MDD and BD on a controlled genetic background.

Source: Stem Cell Research

DOI: 10.1016/j.scr.2026.103920