Work

Synaptic Tuning of Brain Rhythms: From Chemical Signalling to Cortical Oscillations

Year: 2026

Type: article

Abstract: Stoof et al. investigate why distinct brain regions exhibit characteristic oscillatory frequencies, such as occipital alpha and frontal beta rhythms. Their work elegantly links openly available intracranial EEG spectra from 106 epilepsy patients to synaptic receptor densities from available autoradiography maps in three healthy donors. In the framework of dynamic causal modelling, they show that regional oscillations emerge from balanced combinations of excitatory (AMPAR, NMDAR) and inhibitory receptors (GABAR A or B), while neuromodulatory receptors exert subtler influences.

Source: Human Brain Mapping

DOI: 10.1002/hbm.70463

Authors: Maxime O. Baud, Dimitri Van De Ville

Institutions: University of Bern, University Hospital of Bern, University of Geneva, École Polytechnique Fédérale de Lausanne

Language: English

Topic: Neural dynamics and brain function

Subfield: Cognitive Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,520