Work

Erforschung und Adressierung der MCT8-Defizienz durch MCT8/OATP1C1-dKO-Gehirntranskriptomik, neuartige MCT8-Cre Linien, und Peptid-TH-Chimären

Year: 2025

Type: dissertation

Abstract: Deficient transport of thyroid hormones due to mutations in the transporter MCT8 lead to severe neurodevelopmental disorders summarized as the Allan-Herndon-Dudley syndrome. The cell-biological consequences of the deficient thyroid hormone transport were investigated by single nucleus RNA sequencing of the cortex of the MCT8/OATP1C1 mouse model. For the targeted characterization of MCT8-expressing cells an MCT8-CreERT2 mouse line was generated and validated.

Authors: Molenaar, Anna Maria Wilhelmina, Pfluger, Paul Thomas 1973-, Technische Universität München

Language: English

Topic: Thyroid Disorders and Treatments

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7127226559

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