Work

Accepted Manuscript For "Targeted and Untargeted Mass Spectrometry Do Not Detect Grayanane-Type Toxins in Monotropa uniflora L."

Year: 2025

Type: article

Abstract: Monotropa uniflora L. (“ghost pipe”), is a North American traditional medicinal plant which has recently seen an increase in consumption nation-wide. However, a single 1889 study reported the presence of grayanotoxin I in M. uniflora, generating persistent controversy regarding its safety. It is essential to revisit this claim of toxicity given its resurgence in popularity. We applied more sensitive analytical techniques to determine the possible presence of grayanotoxins in a diverse sampling of M. uniflora, using targeted mass spectrometry and MS2-based molecular networking. Across 50 M. uniflora samples, neither grayanotoxins nor structural analogs were detected, refuting the earlier analysis.

Source: ScholarSphere (Penn State Libraries)

Authors: Savannah Anez, Daghan Breen Flail, Eric Paul Burkhart, Joshua J. Kellogg

Language: English

Topic: Plant-based Medicinal Research

Subfield: Pharmacology

Field: Pharmacology, Toxicology and Pharmaceutics

Domain: Life Sciences

Open Access status: green

OpenAlex ID: W7127246115

FWCI:

Cites:

Cited by:

Related to: