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Vulval Lichen Sclerosus Associated With Immune Checkpoint Inhibitor Therapy: A Case Series of 11 Patients

Year: 2026
Type: article
Study design: Observational Study
Abstract: There have only been a limited number of case reports that have described vulval lichen sclerosus in patients receiving immune checkpoint inhibitor (ICI) therapy. We describe 11 cases of vulval lichen sclerosus in patients with melanoma treated with ICIs, and in nine of these cases, the lichen sclerosus symptoms began after ICI commencement. This represents the largest reported series to date and highlights the need for clinician awareness of this potential immune-related adverse effect.
DOI: 10.1111/ajd.70058
Authors: Sophie Walter, Francesca Watts, Raquel Ruiz Araujo, Thevaki Wain, Amanda Glanz, Diona Damian, Matteo S. Carlino, Alexander M. Menzies, Georgina V. Long, Linda K. Martin
Institutions: UNSW Sydney, Royal Prince Alfred Hospital, The University of Sydney, Westmead Hospital, Melanoma Institute Australia, Blacktown & Mount Druitt Hospital, Royal North Shore Hospital
Language: English
Subfield: Oncology
Field: Medicine
Open Access status: hybrid
Estimated APC paid: $4,160
OpenAlex ID: W7127283705
FWCI:
Cites: 9
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