Work

An LLM-Based Intelligent Agent and Its Application in Making the Lanolin Saponification Process Greener

Year: 2026

Type: article

Abstract: Objectives: The industrial production of lanolin alcohol currently employs batch saponification, which suffers from high energy consumption, prolonged processing time, and excessive solid waste generation, rendering it incompatible with green chemistry principles. This study aimed to develop an efficient, sustainable saponification process by addressing these limitations through integrating large language models (LLMs) with microfluidic technology. Methods: An LLM-based intelligent agent called SapoMind (version 1.0) was constructed. SapoMind employs LLMs as its software core and a continuous-flow microreactor as the experimental platform. Its performance was enhanced through supervised fine-tuning. The system enables automated recommendation of saponification process parameters, autonomous experimental design, and automatic execution of experiments. Saponification conditions were automatically optimized considering product quality, energy consumption, material consumption, and time consumption. Results: The optimal continuous-flow saponification conditions were determined as 70 °C reaction temperature and 9 min residence time, producing lanolin alcohol complying with European Pharmacopoeia standards. Compared to batch processing, the optimized process reduced carbon emissions by 53% and solid waste by 37%, with the greenness score increasing from 82 to 93. Conclusions: This study demonstrates the effectiveness of LLM-driven intelligent agents in optimizing green chemical processes. SapoMind offers significant environmental and operational benefits for lanolin alcohol production.

Source: Pharmaceuticals

DOI: 10.3390/ph19020264

Authors: Qinglin Wang, Yu Wang, Xingchu Gong

Institution: Zhejiang University

Language: English

Topic: Innovative Microfluidic and Catalytic Techniques Innovation

Subfield: Biomedical Engineering

Field: Engineering

Domain: Physical Sciences

SDGs: Responsible consumption and production, Industry, innovation and infrastructure

Open Access status: gold

Estimated APC paid: $3,499