Work

Correlation between the osteoporosis self-assessment tool for Asians index and QCT-derived bone parameters: a cross-sectional analysis of lumbar spine mineral density and content

Year: 2026

Type: article

Abstract: Objective: To correlate the Osteoporosis Self-assessment Tool for Asians (OSTA) index with lumbar QCT-measured bone mineral density (BMD) and bone mineral content (BMC), and assess its utility in evaluating lumbar spine BMD/BMC. Methods: From Jan 2023 to Jun 2024, 366 patients scheduled for lumbar spine surgery were enrolled. All underwent lumbar CT, QCT, and DXA. Spearman correlation analyzed OSTA vs. QCT-BMD and QCT-BMC. Patients were categorized by DXA T-scores into osteoporotic or non-osteoporotic groups. ROC curves were plotted to determine AUC, optimal cutoff, sensitivity, and specificity. Results: < 0.01). Based on DXA diagnosis, QCT-BMC yielded AUCs of 0.712 (men) and 0.745 (women) for osteoporosis, indicating moderate diagnostic value. The optimal cutoffs were 663.86 mg for men and 521.65 mg for women, with sensitivities of 57.6% and 59.5%, respectively. Conclusion: As a screening tool, the OSTA index can help identify high-risk individuals undergoing spinal surgery who are likely to have low lumbar trabecular BMD and BMC as measured by QCT. Diagnostic thresholds for osteoporosis may be set at lumbar QCT-BMC <663.86 mg in men or <521.65 mg in women.

Source: Frontiers in Surgery

DOI: 10.3389/fsurg.2026.1752041

Authors: Cheng Li, Yang Lin, Wenyong Jiang, Ye Wang, Xuehui Chang, Fan Yang

Language: English

Topic: Bone health and osteoporosis research

Subfield: Orthopedics and Sports Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,801

Funder: National Natural Science Foundation of China