Work

The oncolytic vesicular stomatitis virus VSV-GP shows profound oncolytic activity in NUT-carcinoma cell lines

Year: 2026

Type: article

Abstract: assays, and FACS analysis; as well as (3) explored potential resistance mechanisms in seven human NC cell lines. Upon infection with VSV-GP, we noticed profound oncolysis, apoptosis, and high replication kinetics in five out of seven NC cell lines. Investigations of molecular determinants of resistance showed that VSV-GPs' entry receptor α-dystroglycan was equally expressed by VSV-GP-permissive and -resistant cell lines. While synthesis of intrinsic interferon (IFN)-β was found to be suppressed in VSV-GP-infected NC cell lines, intracellular IFN-β signaling was functional. Since VSV-GP is a promising compound for virotherapy of NC patients, exploration of virus-induced immunogenicity and identification of resistance mechanisms could pave the way for additional combination treatment regimes in NC.

Source: Molecular Therapy Oncology

DOI: 10.1016/j.omton.2026.201140