Work

Glycomic Insights in Gynecological Disease: From Molecular Mechanisms to Precision Diagnostics and Therapeutics

Year: 2026

Type: article

Abstract: Gynecological diseases-encompassing polycystic ovary syndrome, endometriosis, infertility, and malignancies-represent a significant global health burden affecting women's quality of life, reproductive capacity, and long-term health outcomes. While traditional diagnostics rely on protein-based biomarkers, clinical phenotyping, and imaging, these approaches often lack the sensitivity and specificity required for early detection and personalized intervention. Glycomics, the comprehensive study of carbohydrate structures on proteins and lipids, represents an emerging molecular frontier in gynecological disease characterization and therapeutics. This review synthesizes current knowledge regarding glycomic dysregulation across gynecological conditions, elucidates how aberrant glycosylation patterns serve as disease-specific biomarkers, and demonstrates key translational applications, such as glycoform-specific CA-125. By integrating glycomics with complementary omics technologies and artificial intelligence-driven analysis, a transformative diagnostic paradigm is emerging that promises earlier detection, improved risk stratification, and precision-guided therapeutics for women with gynecological disorders.

Source: International Journal of Molecular Sciences

DOI: 10.3390/ijms27031490

Authors: Róbert Pásztor, Csaba Váradi

Institutions: University of Miskolc, Borsod-Abaúj-Zemplén Megyei Kórház és Egyetemi Oktató Kórház

Language: English

Topic: Glycosylation and Glycoproteins Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,499