Year: 2026
Type: article
Abstract: The implementation of mainstream germline genetic testing in breast cancer patients has both benefits and challenges. Multiple aspects need to be considered for the outline of gene panels and the amount of pre-test genetic counselling. Mainstream genetic testing is mainly performed to stratify patients for targeted treatment. In addition, identification of germline pathogenic variants in cancer risk genes may have surgical implications, consequences for surveillance of other organs at risk of cancer, as well as family implications among relatives at risk. To ensure that patients are well informed, the introduction of mainstream genetic testing performed by non-genetic health care specialists requires an adapted pre-test counselling visit. Here, we review the literature and propose a web-based educational session and pocket guide to support implementation of mainstream testing in oncology practice.
Source: BJC Reports
Institutions: Universitat Autònoma de Barcelona, Vall d'Hebron Hospital Universitari, St George's Hospital, St George's, University of London, St George’s University Hospitals NHS Foundation Trust, Institute of Oncology Ljubljana, Pauls Stradiņš Clinical University Hospital, Masaryk Memorial Cancer Institute, Institut Curie, Tartu University Hospital, University of Tartu, University of Copenhagen, Copenhagen University Hospital, Rigshospitalet, Erasmus MC, Medical Genetics Center, University of Cambridge, NIHR Cambridge Biomedical Research Centre, Karolinska University Hospital, Karolinska Institutet
Language: English
Subfield: Genetics
Domain: Life Sciences
Open Access status: gold
Estimated APC paid: $2,690
Funders: Aarhus Universitetshospital, European Commission, Universiteit Leiden, Radboud Universiteit, Erasmus Medisch Centrum, Universitair Ziekenhuis Gent, Karolinska Institutet, Universiteit Gent, Leids Universitair Medisch Centrum, Universitair Medisch Centrum Groningen, Rigshospitalet, Radboud Universitair Medisch Centrum, Pomorski Uniwersytet Medyczny W Szczecinie, Pécsi Tudományegyetem, Medizinische Universität Innsbruck, Haukeland Universitetssjukehus, Centre hospitalier universitaire Sainte-Justine, Universität Innsbruck, Universitätsklinikum Erlangen, Universitätsklinikum Hamburg-Eppendorf, Third Health Programme
OpenAlex ID: W7127350433