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Isolated Cutaneous Perianal Crohn Disease With Rare Perineal Involvement

Year: 2026

Type: article

Abstract: We present a rare case of isolated perianal Crohn disease (iPCD) with perineal involvement in a 28-year-old woman who remained free of luminal gastrointestinal symptoms for more than 10 years. The diagnosis was significantly delayed due to clinical overlap with hidradenitis suppurativa and pilonidal disease. The patient had multiple unsuccessful treatments, including antibiotics, immunosuppressants, and biological agents. Complete remission was ultimately achieved with combination therapy using infliximab and azathioprine. This case underscores the importance of early recognition, accurate differentiation from mimicking conditions, and a multidisciplinary approach to managing iPCD.

Source: Annals of Internal Medicine Clinical Cases

DOI: 10.7326/aimcc.2025.0481

Authors: Ahmed Hussein Subki, Manar Abdullah Makin, Mohannad Abdulrahman Aljehani, Jaudah Al-Maghrabi, Manal Ismail Bokhary

Institutions: Centre Hospitalier de l’Université de Montréal, Université de Montréal, King Faisal Specialist Hospital & Research Centre, University Health Network, University of Toronto, Toronto General Hospital, National Guard Health Affairs

Language: English

Topic: Inflammatory Bowel Disease

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7127355999

FWCI:

Cites: 12

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