Work

Dopamine’s secret agent: serotonin

Year: 2026

Type: article

Abstract: Dopamine suppresses GABA release from striatal terminals in the substantia nigra pars reticulata. Molinari et al. recently demonstrated that this suppression is frequency-dependent—instituting a high-pass filter on striatal ‘direct pathway' transmission—and does not require dopamine receptors. Rather, dopamine upregulates serotonin, activating presynaptic 5HT1B receptors to exert its effects.

Source: Trends in Neurosciences

DOI: 10.1016/j.tins.2025.12.008

Authors: Andrew J. Miller-Hansen, Talia N. Lerner

Institutions: Northwestern University, University of California, San Francisco, Aligning Science Across Parkinson's

Language: English

Topic: Neurotransmitter Receptor Influence on Behavior

Subfield: Cellular and Molecular Neuroscience

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: hybrid

Estimated APC paid: $7,030