Year: 2026
Type: article
Abstract: N,N-Dimethylformamide (DMF) has been a cornerstone solvent in both peptide and organic synthesis due to its excellent solubilizing properties and chemical stability. However, its use has raised significant health and environmental concerns. DMF is classified as a substance of very high concern (SVHC) by the European Chemicals Agency (ECHA) due to its reproductive toxicity and potential for skin absorption, leading to liver damage upon prolonged exposure. Consequently, restrictions on its use have been introduced, encouraging the scientific community to seek safer, more sustainable alternatives. This review provides a comprehensive analysis of the existing literature on alternative solvents to DMF, identifying current gaps or problems, and offering recommendations for future research.
Source: Molecules
Institution: University of Naples Federico II
Language: English
Subfield: Environmental Chemistry
Field: Environmental Science
Domain: Physical Sciences
Open Access status: gold
Estimated APC paid: $3,258
OpenAlex ID: W7127373314