Work

Association of serum methylglyoxal with endothelial dysfunction in patients with type 2 diabetes

Year: 2026

Type: article

Abstract: Aims: To explore the correlation between serum Methylglyoxal (MGO) and endothelial dysfunction in patients with type 2 diabetes mellitus, and to evaluate the clinical value of MGO in the development of diabetes mellitus and its complications. Methods: In this cross-sectional study, we enrolled 250 patients diagnosed with T2MD. Based on flow-mediated dilation (FMD) measurements, the patients were categorized into normal endothelial function group (FMD ≥6.4%, n = 61) and endothelial dysfunction group (FMD <6.4%, n = 189). Analysis of the relationship between MGO and FMD was conducted via Spearman's correlation, partial correlation, and multiple logistic regression. An ROC curve analysis was utilized to quantify the predictive performance of MGO for endothelial function. Results: >0.05). Receiver operating characteristic (ROC) curve: the area of under the ROC curve (AUC) for MGO was 0.785 (OR: 0.73-0.84, p < 0.001). Conclusion: MGO was significantly inversely associated with FMD and endothelial function in T2DM patients, and can be used as a biomarker to assess vascular endothelial health. Detection of serum MGO levels has clinical significance in the prevention of early diabetic vascular disease.

Source: Frontiers in Pharmacology

DOI: 10.3389/fphar.2026.1773149