Year: 2026
Type: article
Abstract: Hippophae rhamnoides L. (Elaeagnaceae), commonly known as sea buckthorn, is a medicinal plant valued for its diverse bioactive constituents and broad therapeutic potential. Phytochemical investigation of its roots led to the isolation of three new 14-noreudesmane-type sesquiterpenoids ( 1 – 3 ), together with sixteen known compounds ( 4 – 19 ). Their structures and absolute configurations were determined using comprehensive spectroscopic analyses and quantum chemical computations of electronic circular dichroism (ECD) spectra and 13 C NMR shifts. Three new sesquiterpenoids ( 1 – 3 ) were tested for their antioxidant, anti-inflammatory, antibacterial, and α -glucosidase inhibitory activities. Unfortunately, none exhibited significant activity under the tested conditions. Among the isolated known compounds, all those displaying α -glucosidase inhibitory and antibacterial activities are pentacyclic triterpenoids. Hippophamide ( 17 ) showed significant DPPH and ABTS radical-scavenging activity. These results enriched the chemical profile of H. rhamnoides roots. Graphical Abstract
Authors: Fatima Abdurrahman Galadanchi, Polina Lopukhina, Sisi Bai, Guohao Dong, Zhongyu Zhou, Haihui Xie, Xiaoyi Wei
Language: English
Subfield: Complementary and alternative medicine
Field: Medicine
Domain: Health Sciences
Open Access status: diamond
Funders: National Natural Science Foundation of China, Chinese Academy of Sciences, Natural Science Foundation of Guangdong Province, Chinese Academy of Forestry, Kunming Institute of Botany, Chinese Academy of Sciences, Institute of Botany, Chinese Academy of Sciences, Science and Technology Planning Project of Guangdong Province
Awards: G5769088742, G6122630860, G7189696467
OpenAlex ID: W7127388692