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Depletion of Sorcs3 Activates Totipotency in Mouse Embryonic Stem Cells by Modulating Key Signaling Pathways (Adv. Sci. 7/2026)

Year: 2026

Type: article

Abstract: Depletion of Sorcs3 Activates Totipotency In their Research Article (DOI: 10.1002/advs.202509151), Yuan Shi, Qian Gao, Ling Shuai, and colleagues report that knocking out sorcs3 or inhibiting three key pathways can efficiently activate the totipotency of stem cells. The hall of totipotency is a lofty and desirable goal, and the path to it is fraught with challenges. The findings of this study are like a shortcut to aid the climb toward totipotency.

Source: Advanced Science

DOI: 10.1002/advs.73665

Authors: Wenhao Zhang, Xinyu Mao, Yu He, Qingshen Jia, Yiding Zhao, Xiaomeng Dai, Xiaoyan Li, Shengyi Sun, Xiaoyan Sheng, Dan Ding, Yuan Shi, Qian Gao, Ling Shuai

Language: English

Topic: Pluripotent Stem Cells Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $6,730

OpenAlex ID: W7127413586

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