Work

Mixed Adenoneuroendocrine Carcinoma ( MANEC ) of the Stomach: A Case Report in a 52‐Year‐Old Male Following Total D2 Gastrectomy

Year: 2026

Type: article

Abstract: Gastric MANEC (gMANEC) is a rare tumor composed of at least 30% each adenocarcinoma and neuroendocrine carcinoma (NEC) components. A 52-year-old male underwent total D2 gastrectomy for gastric cancer. Final pathology revealed MANEC. We compare outcomes and mortality rates between gastric MANEC and conventional adenocarcinoma. MANEC has poorer disease-free survival (DFS) and post-recurrence survival (PRS), and higher risk of distant recurrence, compared with clear adenocarcinoma. Rigorous follow-up and adjuvant therapy tailored to the more aggressive component are advised.

Source: Clinical Case Reports

DOI: 10.1002/ccr3.71738

Authors: Paraskeva Aikaterini, Triantafyllidhs Alexandros

Institutions: Evangelismos Hospital, NIMTS Hospital

Language: English

Topic: Gastric Cancer Management and Outcomes

Subfield: Pulmonary and Respiratory Medicine

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,820