Year: 2026
Type: article
Abstract: This review paper highlights latest updates on the phytochemistry of Cannabis sativa. Cannabis sativa has been used for thousands of years in therapeutic, recreational, and cultural contexts. Cannabis sativa contains a peculiar class of phytochemicals known as phytocannabinoids, present almost exclusively in its inflorescences. Phytocannabinoids represent the most important and promising specialized/secondary metabolites from Cannabis sativa L. Furthermore, ∆9-Tetrahydrocannabinol (THC) and the corresponding acid tetrahydrocannabinolic acid A (THCA-A), cannabidiol (CBD), cannabinol (CBN), and cannabidiolic acid (CBDA) are the main components of this class. The recently discovered cannabinoid ∆9 -Tetrahydrocannabiphorol (∆ 9 -THCP) was initially known as synthetic derivative, but has been successfully isolated from Cannabis sativa, resulting in a product 30 times more active than ∆9 -THC, the main psychotropic compound of Medical Cannabis sativa (marijuana). Another newly discovered cannabinoid has been called cannabitriol and can be considered a new CBD derivative. Further cannabinoids have recently been characterized, such as cannabiwinol CBDD, anhydrocannabimovone, isolated for the first time as a natural product, and three new hydroxylated CBD analogues: 1,2-dihydroxycannabidiol, 3,4-dehydro-1,2- dihydroxycannabidiol, and hexocannabitriol, obtained from the crystallization of CBD.
Institution: Mangalore University
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: hybrid
OpenAlex ID: W7127507833