Year: 2025
Type: article
Study design: Observational Study
Abstract: As cannabis use has increased steadily over the past decade, there is critical need to evaluate early cannabis use as a potential risk factor for the development of psychosis. Neurobehavioral mechanisms underlying novelty salience could clarify how cannabis exposure may influence subclinical psychotic-like experiences (PLEs). The present study leveraged dynamic functional connectivity and task-fMRI to assess the role of novelty processing in cannabis use and PLEs. A group of brain regions dynamically tied to the salience network while viewing short films were found to increase their activation as a function of stimulus novelty during a novelty bandit task. PLEs were associated with the interaction between novelty encoding in a region of temporo-occipital cortex and exploration to gain rewards. This interaction was specific to those with a history of cannabis use, suggesting a potential neurobehavioral mechanism linking cannabis exposure and PLEs during adolescent through young adult development.
Author: Campbell, Ethan
Institution: University of New Mexico
Language: English
Subfield: Pharmacology
Field: Medicine
Domain: Health Sciences
Open Access status: green
OpenAlex ID: W7127545660
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