Work

Characterization of an induced pluripotent stem cell line (SDCHi010-A) from a young patient with epilepsy

Year: 2026

Type: article

Abstract: Epilepsy is a group of chronic brain disorders characterized by recurrent, episodic, and transient dysfunction of the central nervous system caused by abnormal, excessive neuronal discharges. In this study, peripheral blood mononuclear cells (PBMCs) were isolated from a young patient bearing an FGF12 gene mutation and suffering from clinically and genetically diagnosed epilepsy. Induced pluripotent stem cells (iPSCs) were established using a non-integrative method involving plasmids carrying OCT4, SOX2, KLF4, BCL-XL, and C-MYC. The resulting iPSCs exhibited typical pluripotent cell morphology, a normal karyotype, and the potential to differentiate into all three germ layers.

Source: Stem Cell Research

DOI: 10.1016/j.scr.2026.103923

Authors: Qiaorong Li, Huan Zhang, Wandong Hu, Wenchao Zhang, Pingping Tian

Institution: Shandong University

Language: English

Topic: Pluripotent Stem Cells Research

Subfield: Molecular Biology

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,360