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Percutaneous Mechanical Aspiration of Bioprosthetic Tricuspid Valve Vegetation and Thrombi in Drug Use-Associated Infective Endocarditis

Year: 2026

Type: article

Abstract: Valve Vegetation and Thrombi in Drug Use-Associated Infective EndocarditisA 27-year-old male with a history of intravenous drug use presented with recurrent fungal prosthetic tricuspid valve endocarditis and septic emboli, six months after a prior bioprosthetic valve replacement for methicillin-susceptible Staphylococcus aureus (MSSA) infective endocarditis (IE).Given high surgical risk, he underwent percutaneous mechanical aspiration (PMA) of the valve vegetation and right atrial thrombi using a Penumbra 16F catheter system.PMA was well tolerated, achieved a >50% reduction in vegetation burden, and modest improvement to transvalvular gradient (11 to 6 mmHg).This case supports expanding PMA applications in high-risk drug use-associated infective endocarditis.

Source: CJC Open

DOI: 10.1016/j.cjco.2026.01.013

Authors: Tiffany Furneaux, Ashar Pirzada, Frederic Paulin, Alison Greene, Scott Harris, Mohammad Almutawa

Institutions: Memorial University of Newfoundland, Newfoundland and Labrador Health Services, St. John’s Health Sciences Centre

Language: English

Topic: Infective Endocarditis Diagnosis and Management

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $2,590