Work

Therapeutic targeting of the AMPK-Has1 complex formation ameliorates metabolic dysfunction-associated steatohepatitis in mice

Year: 2026

Type: article

Abstract: Ele protects against MASH by interrupting AMPK/Has1 interaction, regulating lipid metabolism, and restoring mitochondrial function. Collectively, these findings highlight Ele as a potential therapeutic agent and Has1 as a novel target for MASH treatment.

Source: Theranostics

DOI: 10.7150/thno.120527

Authors: Xunzhe Yin, Wenjing Zhao, Li Yang, Chang Li, Xiangyu Guo, Lihao Lin, Zuojia Liu, Jin Wang

Institutions: Chinese Academy of Sciences, Changchun Institute of Applied Chemistry, State Key Laboratory of Electroanalytical Chemistry, Wenzhou Institute, University of Chinese Academy of Sciences, Stony Brook University

Language: English

Topic: Liver Disease Diagnosis and Treatment

Subfield: Epidemiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,671

OpenAlex ID: W7127626164

FWCI: 8.551

Cites:

Cited by: 2

Related to: