Work

2-(3′,5′-Bis((dodecyloxy)carbonyl)-2′,6′-dimethyl-1′,4′-dihydro-[3,4′-bipyridin]-1-ium-1-yl)-1,3-dioxo-2,3-dihydro-1H-inden-2-ide

Year: 2026

Type: article

Abstract: Indane-1,3-dione and 1,4-dihydropyridine (1,4-DHP) scaffolds are of significant interest in medicinal chemistry. Herein, we report the synthesis characterization of a new lipid-like indane-1,3-dione–1,4-DHP betaine, 2-(3′,5′-bis((dodecyloxy)carbonyl)-2′,6′-dimethyl-1′,4′-dihydro-[3,4′-bipyridin]-1-ium-1-yl)-1,3-dioxo-2,3-dihydro-1H-inden-2-ide (3). Compound 3 was synthesized from 2,2-dicyanomethylideneindan-1,3-dione (1) oxide and a didodecyl-substituted 1,4-DHP derivative 2 and characterized by UV–Vis spectroscopy, 1H-NMR, 13C-NMR, and HRMS. The obtained results demonstrate a promising strategy for the design of delivery agents, exploiting the lipid-like properties of the synthesized betaine.

Source: Molbank

DOI: 10.3390/m2133

Authors: Mara Plotniece, Krista Arule, Karlis Pajuste, Aiva Plotniece, Arkadij Sobolev

Institutions: Riga Technical University, Latvijas Organiskās Sintēzes Institūts, Riga Stradiņš University

Language: English

Topic: Synthesis and biological activity

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: gold

Estimated APC paid: $603

Funder: European Commission