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Probiotic Supplementation Reduces RRTIs and Enhances Gut Microbial and Immunity in Children: A Randomized Controlled Trial

Year: 2026

Type: article

Study designs: Randomized Controlled Trial, Clinical Trial

Abstract: < 0.05). Gut microbiota profiling showed clear community differences between groups at day 180, with the probiotic group exhibiting greater abundance of beneficial commensal taxa and the placebo group showing higher representation of opportunistic genera. Functional pathway analysis indicated shifts consistent with enhanced metabolic stability in probiotic recipients. Immune biomarker patterns further supported a more regulated humoral response in the probiotic group, reflected by comparatively stable IgG, IgM, and complement C3 levels over the intervention period. Growth trajectories remained normal in both groups, and no treatment-related adverse events were reported, confirming a favorable safety profile. These findings indicate that long-term supplementation with XLTG11 and CCFM8661 is safe, well tolerated, and effective in reducing RRTI burden in children, while also supporting healthier microbiota and immune patterns. This trial provides evidence for the use of strain-defined probiotics as a complementary approach within pediatric respiratory infection prevention strategies.

Source: Journal of Microbiology and Biotechnology

DOI: 10.4014/jmb.2511.11038

Authors: Ke Chen, Weiwei Ma, Jiayi Zhong, Ping Yang, Nianyang He, Xiaohui Li, Yue Zhai, Jie Yuan, Min-Tze Liong, Changqi Liu, Yuxiu Guan

Institutions: University of Electronic Science and Technology of China, Chengdu Women's and Children's Central Hospital, Heilongjiang University of Chinese Medicine, San Diego State University

Language: English

Topic: Probiotics and Fermented Foods

Subfield: Food Science

Field: Agricultural and Biological Sciences

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W7127641808

FWCI:

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