Work

Additional file 1 of Calcineurin depletion coincides with phosphorylated TDP-43 deposition in a mouse model of ALS/FTLD-TDP

Year: 2026

Type: other

Abstract: Supplementary Material 1. Figure S1: Phosphorylated TDP-43 in rNLS8 mouse brain appears at symptomatic timepoints. Representative images of phosphorylated TDP-43 immunostaining in control animals, and rNLS8 animals at 1 week, 4 weeks, and 7 weeks post-induction. a–d hippocampus, e–h motor cortex, and i–l dorsal striatum. No phosphorylated TDP-43 was detected in control animals or in rNLS8 animals at 1 week post-induction. Arrows point to representative phosphorylated TDP-43 inclusions. Scale bars: 25 µm.

Source: Figshare

DOI: 10.6084/m9.figshare.31246296

Authors: Waldherr, Sarah M., Eck, Randall J., Hincks, Joshua C., Currey, Heather N., Goldberg, Matvey, McMillan, Pamela J., Saxton, Aleen D., Hulsey-Vincent, Heino J., Latimer, Caitlin S., Kraemer, Brian C., Liachko, Nicole F.

Institutions: University of Washington, Geriatric Research Education and Clinical Center

Language: English

Topic: Amyotrophic Lateral Sclerosis Research

Subfield: Clinical Neurology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: green

OpenAlex ID: W7127651229

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