Work

NPM1 phosphorylation-mediated telomere maintenance via stabilization of POLD3 in ALT-positive osteosarcoma: unraveling mechanisms and therapeutic opportunities

Year: 2026

Type: article

Abstract: This study uncovers a novel CST/pT199-NPM1/POLD3 regulatory module that is critical for ALT telomere maintenance in OS. Targeting NPM1 or its downstream effectors effectively suppresses ALT activity and enhances chemotherapy response. These findings provide new mechanistic insights into telomere regulation in ALT-positive tumors and highlight the therapeutic potential of NPM1-centered pathways in OS.

Source: Theranostics

DOI: 10.7150/thno.108662

Authors: Rui Zhao, Tingfang Li, Qiuhui Yang, Duo Jiang, Yanan Xue, Haomeng Kou, Qianqian Wang, Yuwen Wang, Xinyu Han, Wenbin Ma, Guowen Wang, Jinyan Feng, Xiuxin Han, Yancheng Liu, Yaqing Jing, Xin Geng, Fei Wang, Yang Liu, Qiang Zhang, Feng Wang

Institutions: Tianjin Medical University General Hospital, Tianjin Medical University, Ningxia Medical University, Tianjin Medical University Cancer Institute and Hospital, Sun Yat-sen University, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin Hospital

Language: English

Topic: Telomeres, Telomerase, and Senescence

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $1,671

OpenAlex ID: W7127653238

FWCI: 3.926

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Cited by: 1

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