Work

Epilepsy in Children With Central Nervous System Infections: a Systematic Review and Meta-analysis

Year: 2025

Type: review

Study designs: Systematic Review, Meta-Analysis

Abstract: In childhood, infections of the central nervous system may lead to neurodevelopmental disorders and complications such as epilepsy. The present study aimed to evaluate epilepsy in children with central nervous system (CNS) infections. The present systematic review and meta-analysis included five cohort studies from international databases, PubMed, Scopus, Web of Science, and Embase, from January 1, 2010, to May 10, 2025, using keywords aligned with the study objective. The statistical analysis was performed using Stata/MP v17 and a random-effect model. The risk ratio of epilepsy in children with etiologically diagnosed CNS infections was 0.23 (ES = 0.23; 95% CI 0.01 to 0.45; I2 = 99.52%, P < 0.05). Based on the results of the present study, there is a high risk of epilepsy associated with brain infections.

Source: AFMN Biomedicine

DOI: 10.65641/afmnai-2025-169

Authors: Mahsa Afrand, Niusha Rostampur, Zeinab Pourhadi, Javad Rezanezhad, Pouriya Nekoueifard

Institutions: Shiraz University of Medical Sciences, Children's Medical Center, Tehran University of Medical Sciences, Iran University of Medical Sciences

Language: English

Topic: Epilepsy research and treatment

Subfield: Psychiatry and Mental health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

OpenAlex ID: W7127655286

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