Work

Association of TNF-⍺ promoter polymorphisms with COVID-19 susceptibility and severity: a study from South India

Year: 2026

Type: article

Abstract: Background −1031 (T/C) and AA for − 308 (G/A) showing a higher risk for disease susceptibility (OR = 3.5 and 8.7, respectively) and severity (OR = 1.99 and 8.59, respectively). Elevated levels of all biochemical markers were significantly correlated with higher severity of disease. Haplotype analysis demonstrated that individuals with variants at both loci exhibited the highest risk (OR = 3.67) for COVID-19. Conclusion These findings suggest that TNF-α polymorphisms may serve as potential genetic markers for predicting COVID-19 susceptibility and progression in South Indian population.

Source: Egyptian Journal of Medical Human Genetics

DOI: 10.1186/s43042-026-00842-8

Authors: M. L. N. Deepika, Aryan Gupta, C. Lalitha Pavani

Institution: Institute of Genetics and Hospital for Genetic Diseases

Language: English

Topic: Genetic Associations and Epidemiology

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7127891855