Year: 2026
Type: article
Abstract: Hepatocellular carcinoma (HCC) remains one of the most lethal malignancies worldwide, largely due to late diagnosis and limited therapeutic options. Tumor hypoxia is a hallmark of HCC and drives aggressive disease behavior, in part through activation of hypoxia-inducible factors (HIFs). While HIF-1α is classically understood as a hypoxia-responsive transcription factor, its role under normoxic conditions in cells is less clear. The study presented by Gkotinakou and colleagues in this issue provides important insight into this question by revealing a previously underappreciated dependence of HIF-1 signaling in controlling cell cycle progression in HCC, even in the presence of normal oxygen levels.
Source: FEBS Journal
DOI: 10.1111/febs.70440
Authors: Niall S. Kenneth, Michael Batie, Sonia Rocha
Institution: University of Liverpool
Language: English
Subfield: Cancer Research
Domain: Life Sciences
Open Access status: hybrid
Estimated APC paid: $5,000
Funders: Wellcome Trust, Worldwide Cancer Research
OpenAlex ID: W7127902383