Work

The Role of the Delta Neutrophil Index, Pan‐Immune Inflammation Value and Other Hematologic Inflammatory Parameters in the Preliminary Diagnosis of Tubal Ectopic Pregnancy

Year: 2026

Type: article

Abstract: ABSTRACT Background Differentiating between healthy intrauterine pregnancy (HP) and ectopic pregnancy (EP) in early gestation is clinically challenging. Aim This study aimed to evaluate the role of the delta neutrophil index (DNI), pan‐immun inflammation value (PIV) and other hematologic inflammatory markers in the preliminary diagnosis of tubal EP. To the best of our knowledge, there are no studies in the literature examining the relationship between DNI, PIV and EP. Materials and Methods This retrospective study included 120 women diagnosed with tubal EP and 102 women with HP who presented to a tertiary hospital in Turkey between 2019 and 2023. Inclusion criteria were women with confirmed tubal EP or HP who had complete clinical and hematologic data and no chronic diseases, infections, or body mass index (BMI) > 30 kg/m 2 . The primary outcome was to assess whether DNI, PIV and other complete blood count (CBC) parameters could differentiate EP from HP. Statistical analysis included t ‐tests, Welch's t ‐test, χ 2 tests, and ROC analysis; p < 0.05 was considered statistically significant. Results No significant difference was found in DNI value ( p = 0.256). However, white blood cell count (WBC) ( p = 0.007), platelet (PLT) ( p = 0.001), lymphocyte ( p < 0.001), PIV ( p = 0.023), systemic immune‐inflammation index (SII) ( p = 0.016) and basophil ( p = 0.005) levels were higher in the EP group, while hemoglobin (HB) levels were lower ( p < 0.001). Conclusion While DNI was not a significant marker, other hematologic parameters may support early identification of EP, suggesting an underlying inflammatory process.

Source: Immunity Inflammation and Disease

DOI: 10.1002/iid3.70349

Authors: Şeyma Nur Karadag, Dilay Gök Korucu

Institutions: Sağlık Bilimleri Üniversitesi, Konya City Hospital

Language: English

Topic: Ectopic Pregnancy Diagnosis and Management

Subfield: Public Health, Environmental and Occupational Health

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,300