Work

Medical Treatment of Hyperthyroidism; Efficacy and Safety Considerations

Year: 2025

Type: article

Abstract: Antithyroid drugs (ATDs) are often the first treatment option for hyperthyroidism due to their efficacy and safety profile. Long-term ATD treatment can effectively control hyperthyroidism and prevent relapse. In this review, we summarize the findings of clinical trials and clinical experiences on the use of ATD treatment for hyperthyroidism. We discuss the efficacy and safety of ATD treatment, as well as the optimal duration of treatment. The evidence suggests that ATD therapy is selected as initial therapy, treatment of relapse of hyperthyroidism and in patients with persistent elevation of TSH receptor antibodies after 18 months of ATD therapy. Long-term ATD treatment can be an effective and safe option for management of many patients with hyperthyroidism. However, additional studies are needed to establish the most efficacious treatment duration and to identify patients who are most likely to benefit from long-term ATD treatment.

Source: Archives of Iranian Medicine

DOI: 10.34172/aim.33502

Authors: Fereidoun Azizi, Hengameh Abdi, Seyed Alireza Ebadi, Ladan Mehran, Atieh Amouzegar

Institutions: Research Institute for Endocrine Sciences, Shahid Beheshti University, Shahid Beheshti University of Medical Sciences

Language: English

Topic: Thyroid Disorders and Treatments

Subfield: Endocrinology, Diabetes and Metabolism

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: hybrid

Funder: Shahid Beheshti University of Medical Sciences