Work

Supramolecular Assemblies of Self‐Immolative Janus Dendrimers With Rapid Photodegradation Response

Year: 2026

Type: article

Abstract: Advanced supramolecular assemblies with predefined lifetimes and rapid responses to stimuli are in high demand for applications such as biomedical delivery systems. However, such assemblies are rarely able to respond rapidly and completely to stimuli, with predictable changes in morphology. Here, we introduce monodisperse self-immolative Janus dendrimers (SIJDs) composed of hydrophilic oligo(ethylene glycol)-functionalized phenolic acid dendrons and hydrophobic monodisperse oligo(ethyl glyoxylate) chains having light-responsive end-groups. These SIJDs self-assemble into spherical nanoparticles in aqueous media. Upon ultraviolet (UV) light irradiation, the hydrophobic oligo(ethyl glyoxylate) units exhibit rapid end-to-end self-immolation within minutes. The depolymerization at the molecular level leads to a degradation pathway from spherical to crescent-shaped nanoparticles, which can be used for the rapid release of encapsulated molecules of interest.

Source: Small

DOI: 10.1002/smll.202511067

Authors: Chuanfeng Li, Jiabin Luan, Daniela A. Wilson, Elizabeth R. Gillies

Institutions: Western University, Radboud University Nijmegen

Language: English

Topic: Dendrimers and Hyperbranched Polymers

Subfield: Polymers and Plastics

Field: Materials Science

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $5,790

Funders: European Commission, Canada Excellence Research Chairs, Government of Canada, Natural Sciences and Engineering Research Council of Canada, H2020 European Research Council