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From byproduct to biotherapeutic: Comparative study of buffy coats and leukoreduction system chambers for NK cell-based immunotherapies

Year: 2026

Type: article

Abstract: cells. They also show enhanced proliferative capacity over sixteen days. Phenotyping of source materials reveals higher fractions of NK and B cells in LRSCs, suggesting effects of the donation modality or donor characteristics warranting further study. Altogether, our findings support LRSCs as a practical and economical NK cell source for research and method development with clear potential for clinical translation.

Source: iScience

DOI: 10.1016/j.isci.2026.114907

Authors: Maximiliane Tietze, Maria Schuldt, Martina Wohsmann, Kristina Hölig, Helmut Hanenberg, Torsten Tonn, Jiri Eitler, Joel G. Rurik, Stephan R. Künzel

Institutions: German Red Cross, Technische Universität Dresden, University Hospital Carl Gustav Carus, Düsseldorf University Hospital, Heinrich Heine University Düsseldorf, University of Duisburg-Essen, Goethe University Frankfurt, University Hospital Frankfurt, German Cancer Consortium (DKTK) Dresden, Karolinska Institutet

Language: English

Topic: Immune Cell Function and Interaction

Subfield: Immunology

Field: Immunology and Microbiology

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: gold

Estimated APC paid: $3,240

Funders: Deutsche Forschungsgemeinschaft, Bundesministerium für Bildung und Forschung, Cancerfonden, Deutsches Rote Kreuz

Awards: SaxoCell: Ex vivo-modifizierte Natürliche Killerzellen zur Immuntherapie von Tumoren und Autoimmunerkrankungen (NK-Alliance) - B, G662888678, G7094193045

OpenAlex ID: W7127921272

FWCI:

Cites: 40

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