Work

Total Synthesis of Conjugation‐Ready Tetrasaccharide Repeating Units of Pseudomonas Aeruginosa (Lányi) O11

Year: 2026

Type: article

Abstract: Herein, we report the first total synthesis of the conjugation-ready tetrasaccharide repeating units of Pseudomonas aeruginosa (Lányi) O11. The all-6-deoxy-sugars containing tetrasaccharides were synthesized using an efficient convergent methodology employing a (2 + 2) glycosylation strategy. A key to this approach is utilizing a common disaccharide donor, which streamlines the assembly of both the tetrasaccharides by minimizing protecting group manipulations and enhancing overall efficiency. The disaccharide donor was synthesized through a highly chemoselective activation of a meticulously designed reactive thioglycoside donor, allowing for precise control over stereochemistry and regioselectivity during the glycosylation.

Source: Chemistry - An Asian Journal

DOI: 10.1002/asia.202500950

Authors: Archana A. Shirsat, Mahak Chhabra, Suvarn S. Kulkarni

Institution: Indian Institute of Technology Bombay

Language: English

Topic: Carbohydrate Chemistry and Synthesis

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: bronze

Funders: Council of Scientific and Industrial Research, India, Indian Institute of Technology Bombay

Award: G3587592859