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Maackiain Reduces Neuroinflammation by Modulating Inflammatory Signals in LPS-Induced In Vitro and In Vivo Models

Year: 2026

Type: article

Abstract: , mice treated with MAA showed improved memory in the Morris water maze compared to the LPS group. Nissl staining revealed fewer IBA-1 positive cells and a decrease in COX-2 and IL-6 levels in the hippocampus and cortex. This compound also increased the number of normal neurons in the cortex and CA3 region. The results of this study highlight the inhibitory effects of MAA on neuroinflammation, suggesting its potential as an effective therapeutic agent for treating neuroinflammation.

Source: Journal of Microbiology and Biotechnology

DOI: 10.4014/jmb.2508.08046

Authors: Tianchan Yun, Yue Xiao, Yanmei Gong, Yanxian Lai, Shiya Huang, Yanqing Ma, Yixi Zeng, Lanyue Zhang, Cong Deng

Institutions: Guangzhou First People's Hospital, South China University of Technology, Guangdong University of Technology

Language: English

Topic: Neuroinflammation and Neurodegeneration Mechanisms

Subfield: Neurology

Field: Neuroscience

Domain: Life Sciences

SDG: Good health and well-being

Open Access status: bronze

OpenAlex ID: W7127925896

FWCI:

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