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Characterization of a nucleic acid‐binding translin‐like protein localized to the basal body in the unicellular green alga Chlamydomonas reinhardtii

Year: 2026

Type: article

Abstract: This study characterizes a translin-like protein from Chlamydomonas reinhardtii, a unicellular alga. The efficient binding of the Crtranslin protein to both single-stranded DNA and RNA aligns it with the nucleic acid-binding properties of the translin protein family, known for its roles in DNA repair, RNA metabolism, and mRNA transport. We report for the first time the presence of a translin-like protein that forms octameric rings, is more closely related to rice translin, and is localized to an organelle not yet known to harbor such a family of proteins, viz., in the basal body and flagella of C. reinhardtii. This study lays the groundwork for future investigations into the molecular functions of Crtranslin and its potential regulatory roles in flagellar dynamics. Impact statement This is the first report of the presence of a nucleic acid-binding protein, Translin, in the basal body and cilia.

Source: FEBS Letters

DOI: 10.1002/1873-3468.70289

Authors: Saptadipa Basak, Hanee Arkate, Dhruv Das, Rajani Kant Chittela, Jacinta S. D'Souza

Institutions: University of Mumbai, Department of Atomic Energy, Center for Excellence in Basic Sciences, Bhabha Atomic Research Centre, Homi Bhabha National Institute

Language: English

Topic: Genetic and Kidney Cyst Diseases

Subfield: Genetics

Field: Biochemistry, Genetics and Molecular Biology

Domain: Life Sciences

Open Access status: bronze

Funders: Bhabha Atomic Research Centre, Tata Memorial Centre

OpenAlex ID: W7127929501

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