Work

HMPA-Enabled Direct γ′-Arylation of Cyclic Vinylogous Esters

Year: 2026

Type: article

Abstract: High Resolution Image Download MS PowerPoint Slide Controlling regioselectivity in deprotonative arylation of conjugated carbonyl systems remains a longstanding challenge. We report a Pd-catalyzed γ′-arylation of cyclic vinylogous esters (CVEs), enabled by Pd(dba) 2 /cataCXium A and hexamethylphosphoramide (HMPA) as a regioselectivity-governing additive. The method accommodates a broad range of (hetero)aryl bromides and CVE substrates. The resulting γ′-aryl CVEs were further converted to α-arylcycloalkenones via Stork–Danheiser transposition.

Source: Organic Letters

DOI: 10.1021/acs.orglett.6c00380

Authors: Yan-Xun Li, Wei-Ting Zhao, Yen-Ku Wu

Institutions: National Yang Ming Chiao Tung University, Chung Yuan Christian University

Language: English

Topic: Catalytic Cross-Coupling Reactions

Subfield: Organic Chemistry

Field: Chemistry

Domain: Physical Sciences

Open Access status: hybrid

Estimated APC paid: $4,500

Funders: National Science and Technology Council, Shanghai Educational Development Foundation, National Tsing Hua University, National Science and Technology Council