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CSF Anti-Sjögren’s Syndrome Antigen A Antibodies and Low Glucose Levels in Sjögren’s Syndrome-Associated Aseptic Meningitis: A Case Report

Year: 2026

Type: article

Abstract: Primary Sjögren's syndrome (pSS) rarely involves the CNS, including cases of aseptic meningitis (AM). We report the case of a 59-year-old woman who presented with headache, fever, and nuchal rigidity. CSF analysis revealed pleocytosis, elevated protein, and decreased glucose levels. Both serum and CSF anti-Sjögren's syndrome antigen A (anti-SS-A) antibody tests were positive, with an elevated CSF anti-SS-A antibody index. Salivary gland biopsy confirmed the diagnosis of pSS. The patient improved following steroid pulse therapy. Reduced CSF glucose levels in combination with positive CSF anti-SS-A antibody tests may serve as supportive clues for pSS-associated AM. Evaluation of autoimmune features and CSF anti-SS-A antibodies may aid in the diagnosis of AM of unclear etiology.

Source: Cureus

DOI: 10.7759/cureus.103059

Authors: Tatsuya Ueno, Ko Hiyama, Ren Yanagida, Maki Miura, Akira Arai

Institution: Aomori Prefectural Central Hospital

Language: English

Topic: Salivary Gland Disorders and Functions

Subfield: Physiology

Field: Medicine

Domain: Health Sciences

SDG: Good health and well-being

Open Access status: diamond

OpenAlex ID: W7127961376